I did a quick Google search and it looks like fluid retention is an infrequent side effect of Cipro. I also saw some other folks were complaining about bloating and swelling after taking Cipro for a couple days. Honestly, I skimmed the info so you can google cipro + water retention if you want more info or look up the side effects of Cipro. You can also call your local pharmacy and ask. Hope that helped some!